Starring: David Letterman Paul Shaffer David Letterman Creator: Eric Stangel Episodes S16 E1: Nicolas Cage, Anna Torv, Terrence Howard S16 E2: Dr. Phil McGraw, Tilda Swinton, Tricky S16 E3: Robin Williams, Shannen Doherty, Duffy S16 E4: John Malkovich, Hayden Panettiere, Steve Earle S16 E5: Keira Knightley, Thomas L. Friedman S16 E6: Jada Pinkett Smith, Chris Russo, Michael Buble S16 E7: Sen. Barack Obama, LeBron James S16 E8: Jessica Simpson, Jack Hanna S16 E9: Meg Ryan, Ricky Gervais S16 E10: Bill Clinton, Chris Rock S16 E11: Julianne Moore, Tom Dreesen & Tim Reid, Kings of Leon S16 E12: Keith Olbermann, Chandra Wilson, Delta Goodrem S16 E13: Paris Hilton, Usain Bolt, Morningwood S16 E14: Lance Armstrong, Kristen Wiig, TV on the Radio S16 E15: Julia Louis-Dreyfus, Michael Cera, Pete Seeger S16 E16: Anne Hathaway, Josette Sheeran, The Virgins S16 E17: Kate Walsh, Barry Sonnenfeld, Darius Rucker S16 E18: Calista Flockhart, Bill Hader, Lucinda Williams S16 E19: Brian Williams, Tim Robbins S16 E20: Russell Crowe, Sarah Vowell, The Pretenders S16 E21: Debra Messing, John Carter, Tegan & Sara S16 E22: Dennis Quaid, Sarah Chalke, Buddy Guy S16 E23: Bill Murray, Beck S16 E24: Jeremy Piven, Elizabeth Banks, Lou Reed S16 E25: Sarah Silverman, the Teutuls, Ra Ra Riot S16 E26: Josh Brolin, Amy Sedaris, Blues Traveler S16 E27: Martin Short, Marv Albert S16 E28: Sen. John McCain, Ne-Yo S16 E29: Tina Fey, Frank Caliendo, Tim Montana S16 E30: Bill O'Reilly, Lauren Conrad S16 E31: Regis Philbin, James Taylor S16 E32: Alec Baldwin, Paul Mooney, Ryan Adams S16 E33: Ashley Olsen, Paul Rudd, John Legend S16 E34: Marcia Cross, Alan Zweibel S16 E35: Paris Hilton, Elvis Costello, Jenny Lewis, a Top Ten List by Ricky Gervais S16 E36: Tom Brokaw, Vera Farmiga S16 E37: Ben Stiller, Q-Tip S16 E38: Natalie Portman, Artie Lange, Brad Paisley S16 E39: Ted Turner, Jamie Oliver, Taylor Swift S16 E40: Don Rickles, Amy Brenneman, Alicia Keys S16 E41: Russell Brand, Charlie Haden S16 E42: Bruce Willis, Sia S16 E43: Bill Cosby, Matt Braunger S16 E44: Emma Thompson, Michelle Felicetta, Purple Reign S16 E45: Carla Bruni Sarkozy, Jack Hanna, Cold Hard Cash S16 E46: Katie Couric, Dev Patel, Mr. Brownstone S16 E47: Stephen Colbert, Kristen Stewart, Super Diamond S16 E48: James Franco, Bruce McCall, The Allstarz S16 E49: Nicole Kidman, Simon Baker, Kanye West S16 E50: Reese Witherspoon, Harry Connick Jr. S16 E51: Teri Hatcher, Ludacris S16 E52: Denis Leary, John Mayer S16 E53: Tom Arnold, Faith Hill S16 E54: Jennifer Connelly, Anderson Cooper, The Duke Spirit S16 E55: Amy Adams, Michael Sheen, Jamey Johnson S16 E56: Keanu Reeves, Paula Abdul, Loudon Wainwright III S16 E57: Sen. John McCain, Bon Iver S16 E58: Meryl Streep, Jeff Altman S16 E59: Adam Sandler S16 E60: Tom Cruise, Fall Out Boy S16 E61: Jennifer Aniston, Broken Social Scene S16 E62: Will Smith, Of Montreal S16 E63: Jerry Seinfeld, Leona Lewis S16 E64: Dustin Hoffman, Todd Rundgren S16 E65: Jay Thomas, Mickey Rourke, Darlene Love S16 E66: Tracy Morgan, Matt Braunger S16 E67: Kate Hudson, Glasvegas S16 E68: Kevin James, Becky Quick, Erin McCarley S16 E69: Ricky Gervais, Rose Byrne, Okkervil River S16 E70: Kate Winslet, Marv Albert S16 E71: Kiefer Sutherland, Wendy Liebman S16 E72: Billy Crystal, Kara DioGuardi S16 E73: Salma Hayek, Jimmie Walker S16 E74: Clint Eastwood, Randy Rogers Band S16 E75: Kyra Sedgwick, Gwen Ifill S16 E76: Zach Braff, Arj Barker, The Airborne Toxic Event S16 E77: Brian Williams, Ben Kweller S16 E78: Evangeline Lilly, Seth Meyers, Andrew Bird S16 E79: Lauren Graham, Guy Fieri, MENEW S16 E80: Renee Zellweger, Tony Dungy, Graham Nash sits in with the band S16 E81: Mary Hicks, the Gaslight Anthem S16 E82: Ben Roethlisberger, Steve Martin S16 E83: Rod Blagojevich, Richard Jenkins S16 E84: Joe Torre, Demetri Martin, Lyle Lovett and John Hiatt S16 E85: Isla Fisher, extreme fisherman Matt Watson, Mark Olson and Gary Louris, a Top Ten List presented by Lil' Wayne S16 E86: Dakota Fanning, Keith Alberstadt, Beirut S16 E87: Naomi Watts, Danny McBride, 2009 Sports Illustrated Swimsuit Issue cover reveal S16 E88: The crew of US Airways "Miracle On The Hudson" Flight 1549, Heartless Bastards S16 E89: Joaquin Phoenix, Bar Refaeli, Anthony Hamilton S16 E90: Chris Russo, the Jonas Brothers, Ashford & Simpson S16 E91: Martha Stewart, Jake Johannsen, Matt Nathanson S16 E92: Ellen Pompeo, Daytona 500 winner Matt Kenseth, Willie Nelson with Asleep at the Wheel S16 E93: Bonnie Hunt, M. Ward S16 E94: Donald Trump, Antony and the Johnsons S16 E95: David Spade, Jeffrey Sachs, David Sanborn with Sam Moore S16 E96: Barbara Walters, Mike Birbiglia, Shemekia Copeland S16 E97: Katie Couric, U2 S16 E98: Felicity Huffman, Artie Lange, U2 S16 E99: Dr. Phil McGraw, U2 S16 E100: Jon Stewart, U2, a Top Ten List featuring 10 Team USA members from the World Baseball Classic S16 E101: Jason Segel, Brian Kiley, U2 S16 E102: Russell Brand, Jack Hanna S16 E103: Stupid Pet Tricks, Paul Rudd, Razorlight S16 E104: Tom Brokaw, An Horse S16 E105: Andy Samberg, Paul Teutul Sr., the Broadway cast of "West Side Story" S16 E106: Will Ferrell, Cursive S16 E107: Nicolas Cage, Rachel Maddow S16 E108: Julia Roberts, Bell X1 S16 E109: Craig Ferguson, Ginnifer Goodwin, Modest Mouse S16 E110: Billy Crystal, Kara DioGuardi, a Top Ten List presented by Owen Wilson S16 E111: David Spade, Richard Zoglin, David Sanborn and Sam Moore S16 E112: Hugh Laurie, Bloc Party S16 E113: Mary Tyler Moore, Blake Lively, White Lies S16 E114: Christina Applegate, Jim Gaffigan, Jesse Harris with Norah Jones S16 E115: Seth Rogen, Tom Dreesen, Adele S16 E116: Bill O'Reilly, Marianne Faithfull S16 E117: Marg Helgenberger, Francisco Palacios, Ray LaMontagne S16 E118: Michael J. Fox, the Fray S16 E119: Denis Leary, Diana Krall S16 E120: Zac Efron, Mike Golic and Mike Greenberg, A.C. Newman with Nicole Atkins S16 E121: Kelly Ripa, Bill Scheft, Yeah Yeah Yeahs S16 E122: Drew Barrymore, Jack McBrayer, Neko Case S16 E123: Matthew Perry, Elisha Cuthbert, Rascal Flatts S16 E124: Russell Crowe, Joe Wong S16 E125: Jeff Goldblum, Jeff Dunham S16 E126: Nathan Lane, Tinted Windows S16 E127: Beyonce, Jim Parsons S16 E128: Jamie Foxx, Lauren Conrad, the Dead S16 E129: Michael Keaton, Lily Allen S16 E130: Matthew Fox, Carol Leifer, the All-American Rejects, a Top Ten List presented by Matthew Stafford S16 E131: Dolly Parton, Zachary Quinto S16 E132: Jennifer Garner, Tesla Motors CEO Elon Musk, Manchester Orchestra S16 E133: Regis Philbin, a performance by the Broadway cast of "Hair" S16 E134: Kiefer Sutherland, Jim Norton, Bat for Lashes S16 E135: Gordon Ramsay, Chris Pine, Keri Hilson with Kanye West S16 E136: Liev Schreiber, Dr. Sanjay Gupta, Franz Ferdinand S16 E137: Bruce Willis, Ben Harper & Relentless7 S16 E138: Norm MacDonald, a Top Ten List presented by Leonard Nimoy, Animal Collective S16 E139: Matthew Broderick, Brian Regan, Chris Cornell S16 E140: Tom Hanks, the Killers S16 E141: Alec Baldwin, Maya Rudolph, Chrisette Michele S16 E142: Robin Williams, Wynton Marsalis S16 E143: Kid Scientists, Teri Hatcher, Rick Ross with Magazeen, a Top Ten List presented by Ron Howard S16 E144: John Goodman, Tommy Tiernan, Mastodon S16 E145: Ben Stiller, White Rabbits S16 E146: Jane Fonda, Piedmont Bird Callers, Kenny Chesney S16 E147: Stephen Colbert, General Motors Vice Chairman Bob Lutz, Grizzly Bear S16 E148: Amy Sedaris, Ed Helms, Jean Redpath S16 E149: Ricky Gervais, Green Day S16 E150: Bill Cosby, Helio Castroneves, Melody Gardot S16 E151: Jack Hanna, John Krasinski S16 E152: Jessica Biel, Zach Galifianakis, Steve Earle S16 E153: Elvis Costello, a Top Ten List presented by Neil Patrick Harris S16 E154: Paris Hilton, Calvin Borel, Steven Wright S16 E155: Howard Stern, Mos Def S16 E156: Julia Roberts, Black Eyed Peas S16 E157: Kathy Griffin, Stupid Human Tricks, Sonic Youth, an NBA Finals report by Phoenix Suns' Steve Nash S16 E158: Denzel Washington, the Jonas Brothers, a Top Ten List with Regis Philbin S16 E159: Sandra Bullock, Pete Correale, P.J. Harvey & John Parish S16 E160: Jack Black, M.A. Sanjayan S16 E161: Michelle Pfeiffer, Judah Friedlander, Ian McLagan & the Bump Band S16 E162: Ryan Reynolds, Padma Lakshmi, the Eels S16 E163: Danny DeVito, Bear Grylls, Phoenix S16 E164: Jada Pinkett Smith, Michael Cera, the Sounds S16 E165: Samuel L. Jackson, Emeril Lagasse, Iggy Pop & the Brighton Port Authority S16 E166: Sandra Day O'Connor, MSTRKRFT with John Legend, a Top Ten List presented by Lucas Glover S16 E167: Ray Romano, St. Vincent S16 E168: Johnny Depp, Megan Fox S16 E169: Martin Short, Regina Spektor S16 E170: Serena Williams, Hayden Panettiere, Conor Oberst and the Mystic Valley Band S16 E171: Sacha Baron Cohen, Joel McHale S16 E172: Queen Latifah, Emma Watson S16 E173: Daniel Radcliffe, Veronika Part, Levon Helm, a Top Ten List presented by Bruno S16 E174: Rainn Wilson, Larry Miller, Maxwell S16 E175: Jonah Hill, Gar Ryness, Kelly Clarkson S16 E176: Edie Falco, Michael Showalter, Wilco with Feist S16 E177: Paul McCartney, a Top Ten List presented by Bruce Willis S16 E178: Anderson Cooper, Anna Paquin, Grizzly Bear S16 E179: Tom Arnold, Metric, a Top Ten List presented by Dave's mom Dorothy S16 E180: Katherine Heigl, Jeff Altman, Spinnerette S16 E181: Kevin Spacey, Jesse James, the Flatlanders, a Top Ten List presented by Stewart Cink S16 E182: Tracy Morgan, Leslie Mann, Diane Birch S16 E183: Sean "Diddy" Combs, Vera Farmiga, Ginuwine with Missy Elliott S16 E184: Amy Poehler, Nick Griffin, Judy Collins S16 E185: Eric Bana, Dave Matthews Band, a Top Ten List presented by Chicago White Sox star Mark Buehrle S16 E186: Katie Couric, Silversun Pickups S16 E187: Amy Adams, Tom Dreesen, Elbow S16 E188: Adam Sandler, Cage the Elephant S16 E189: Regis Philbin, Ted Alexandro, Dave Matthews Band S16 E190: Quentin Tarantino, Eric Ripert, Robert Cray S16 E191: Donald Trump, Diane Kruger, Billy Currington, a Top Ten List presented by Britney Spears S16 E192: Mike Myers, Ken Burns S16 E193: Anna Wintour, Mark Teixeira S16 E194: Renee Zellweger, Gary Mule Deer S16 E195: Christina Applegate, Brendan Benson, Patton Oswalt S16 E196: Anna Wintour, Mark Teixeira S16 E197: Mary-Louise Parker, Eugene Levy, Jet S16 E198: Anne Heche, Jim Parsons, Care Bears on Fire S16 E199: Andy Roddick, Rachael Ray, Mutemath S16 E200: Artie Lange, Todd Barry, Imogen Heap